Adenoviruses: Model and Vectors in Virus-Host Interactions: by G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr.

By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the prior years have noticeable speedy growth within the box of adenovirus learn. additionally, adenoviruses have attracted significant curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity offers with the immune process, oncogenesis and gene remedy.

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Additional info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy

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1, and Table 3). Frequently, these proteins are glycosylated and localize to the ER, Golgi/ TGN, plasma, or nuclear membrane. 7K proteins and their homologues in subgenera A-E and A-F, respectively. 3K open reading frame (ORF) of Ad4 may also encode a cytosolic protein, but its expression has not yet been confirmed. Most E3 proteins are predicted to be type Ia transmembrane proteins with an N-terminal signal sequence (Table 3). 7K, and the 9K ORF present in subgenus Bl lack such an N-terminal sequence, and instead contain a 32 ~ 125 K6 .

1, and Table 3). Frequently, these proteins are glycosylated and localize to the ER, Golgi/ TGN, plasma, or nuclear membrane. 7K proteins and their homologues in subgenera A-E and A-F, respectively. 3K open reading frame (ORF) of Ad4 may also encode a cytosolic protein, but its expression has not yet been confirmed. Most E3 proteins are predicted to be type Ia transmembrane proteins with an N-terminal signal sequence (Table 3). 7K, and the 9K ORF present in subgenus Bl lack such an N-terminal sequence, and instead contain a 32 ~ 125 K6 .

In this review, we will use the term di-Ieucine motif for all of these cases. , the MPRs (Table 2). These most frequent sorting signals will be discussed in more detail in Sect. 2. Certain proteins achieve a steady-state localization in the E E E E CD-MPR (MPR46) CD-MPR (MPR46) RNVPAAYRGV EESEERDDHLLPM E Menkes disease protein CI-MPR (MPR300) CI-MPR (MPR300) E E E E E E E E FcRIl-B2 (mouse) Limp II Invariant chain Transferrin receptor Lamp-1 HLA-DM,8 TGN38/46 LDL receptor SNVSYKYSKV SFHDDSDEDLLHI Sorting motifs in MPRs LL motifs EAENTITYSLLKH EGTADERAPLIRT MDDQRDLISN LISNNEQLPMLGR VTSEPDKHSLLVG GGEPLSYTRF KRSHAGYQTI RAGHSSYTPL RPKASDYQRL YXX motifs NFDNPVY NPXYmotifs B B B B B B B TGN/EE B TGN/EE B TGN/EE B TGN/EE B TGN L MIlC EE L MIlC TGN EE AP-3, GGA1, (3) AP-2, -3 AP-2 AP-1, GGA1, 2, 3 AP-3 AP-1, -2 AP-2 AP-1, -2, -3 AP-1, -2 AP-1, -2 AP-2, Clathrin Adaptor binding Heilker et al.

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