Advances in Nuclear Oncology:: Diagnosis and Therapy by Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar

By Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober

The diagnostic and healing achievements in radiopharmaceuticals and nuclear medication instrumentation ? puppy, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT

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Most frequently they lie within the posterior fossa arising from the lining of the fourth ventricle or cerebellopontine angle, but they may also arise in the filum terminale and the central spinal canal. 21 Supratentorial ependymomas are often larger and have a cystic component. 22 Other primary brain tumors in children include choroid plexus papilloma and carcinoma. They are rare tumors which arise from the cerebral spinal fluid (CSF) producing neuroepithelial tissue. Almost half of these tumors occur under 12 years of age, and represent 2–4% of all pediatric brain tumors.

J Magn Reson Imaging 2001; 13: 882–8. 22. Boellaard R, Knaapen P, Rijbroek A, Luurtsema GJ, Lammertsma AA. Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography. Mol Imaging Biol 2005; 7: 273–85. 23. Bruehlmeier M, Roelcke U, Schubiger PA, Ametamey SM. Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15OH2O. J Nucl Med 2004; 45: 1851–9. 24. Chen X, Park R, Shahinian AH et al.

The most frequent (65%) and most malignant histological subtype of glioma in adults is the glioblastoma, with a peak incidence in the seventh decade and survival of less than 2 years for most patients. Even in low-grade astrocytomas, 5-year survival is only 30% due to malignant progression. If we consider glioma subtypes as distinct entities, the single most frequent brain tumor in adults is not glioma but meningioma. Decreasing frequencies are reported for pituitary adenomas, schwannomas, congenital tumors, and others.

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