Annual Reports in Medicinal Chemistry, 3 by C K Cain

By C K Cain

ANNUAL reviews IN MED CHEMISTRY V3 PPR.

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Halliday, J. Med. Chem. 10(5), 807 (1967). 28. J. G. Topliss, E. P. Shapiro a n d R . I. Taber, J. Med. Chem. 10(4), 642 (1967). 29. J. Mirsky, D. T. Walz, E. Macko and S. Sherman, Federation P r o c . 26(2), 742 (1967). 30. E. Macko, G. W i l z n , L. Greene, A. D. Bender and R. E. Tedeschi, Arch. Int. Pharmacodyn. Ther. 168( l), 220 (1967). 31. F. de Marchi and G. A. Cossa, F a r m a c o , Ed. Sci. 21(12), 878 (1966). 32. V. G. Hofrichter, A. Roesch, E. Roesch and G. Schenk, Arzneimittel-Forsch.

0 times as potent as orally-ingested material 13'. Adverse reactions to marihuana 140 and the problem of dependence 141,14' have been reviewed. Amongst the indoles, 6-fluoro-N,N-diethyltryptamine (6-FDET) produced some of the physical and mood changes of the hallucinogenic N,N-diethyland N,N-dipropyltryptamines. It did not, however, induce the perceptual and thinking changes of these agents and was suggested as an "active placebo" in evaluating the therapeutic ability of hallucinogenic drugs 1 4 3 .

Boitard, J. l e Meur, J. J. B a s s e l i e r , M. Brunaud a n d J. Salle, Chim. Ther. 2(3), 171 (1967). 27. H. R, Snyder, J r . , C. S. Davis, R. K. Bickerton and R. P. Halliday, J. Med. Chem. 10(5), 807 (1967). 28. J. G. Topliss, E. P. Shapiro a n d R . I. Taber, J. Med. Chem. 10(4), 642 (1967). 29. J. Mirsky, D. T. Walz, E. Macko and S. Sherman, Federation P r o c . 26(2), 742 (1967). 30. E. Macko, G. W i l z n , L. Greene, A. D. Bender and R. E. Tedeschi, Arch. Int. Pharmacodyn. Ther. 168( l), 220 (1967).

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