Annual reports in medicinal chemistry. / Volume 8 by Richard V Heinzelman

By Richard V Heinzelman

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A tolerance study indicated r a p i d development of tolerance t o both anormia and mobilization of f a t t y a c i d s . 69 The animals remained responsive t o the administration of exogenous norepinephrine but developed crosstolerance t o the l i p o l y t i c e f f e c t of o t h e r anorectics. Metabolism - The understandin of the metabolism of a n o r e c t i c drugs cont i n u e s t o grow in i m p ~ r t a n c e . 13j s k Dealkylation and deacylation of N-substituted henethylamine anorex- Aromatic hydroxi c s are l i k e l y t o be rapid metabolic processee.

M. I. Gluckman and J. L. &Us, R e f . 3, p. 4-14. M. E. Freed and J. R. Fbtoski, Belg. ht. 776,173 (2 June 1972; t o Am. Home Products Corp. ); c f . a l s o Chem. , 78, 2950% (1973). M. E. Freed, J. Fbtoski, E. H. Freed and J. W l i s , MEDI 20, 165th ACS National Meeting, Dallas, Texas, April 8-13, 1973. M. Takeda and Y. Kcma, Jap. J. , 22, Suppl. a mT & v9+gy, 28 - 41. 42. 43 44. 45 Sect. I - CNS Agents Engelhardt, Ed. M. Ianglois P. Delaunay C. -L. RouS81lon, J. h i l l a r d , R. Mprin an& C.

Kales, Current Therap. , 15, 13 (1973). 7. Leventha1, J. Clin. , l2, 331 (1972). 8. Friis, The Benzodiazepines, Raven Press, New York, 1973, 285. 36 - Sect. I - CNS Agents Engelhardt, Ed. 9. Mucciardi, Pharmakopsychiatrie, Neuro-Psychopharmakoligie, 5, 225 (1972). 10. Hashimoto, Jap. J. Clin. Exp. , 48, 1247 (1971). 11. Yamamoto, Arzneim. , 22, 534 (1972). 12. Suzuki, Arzneim. , 22, 884 (1972). 13. Eichenberger, Psychopharmacologia 28, 325 (1973). 14. Oswald, Proc. Assoc. Psychophysiol. Study of Sleep, 11, 176 (1972).

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