By Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)
This e-book is the results of a global symposium held on the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The reason of this symposium was once to supply a chance to match the knowledge on coronavirus constitution and copy tion in addition to to debate mechanisms of pathogenesis. For over a decade coronaviruses were famous as a big team of viruses that are liable for numerous illnesses of scientific significance in animals and guy. lately new and fascinating information at the molecular biology and pathogenesis of coronaviruses became on hand and this led us to prepare this assembly. The uniformity and variety during this virus team used to be evaluated from a molecular perspective and the replication of coronaviruses looks to contain facets that may be particular for this virus crew. also, unlike different confident strand RNA viruses it turned transparent that coronaviruses with no trouble identify continual infections within the host, a phenomenon that could bring about the several subacute or power issues manifested in the course of coronavirus an infection. This quantity offers a chain of articles dependent upon the clinical presentation given on the symposium. moreover, there are articles via B. W. J. Mahy and D. A. J. Tyrrell which summarize the present country of artwork about the biochemistry and biology of coronaviruses, respective ly. We think this booklet can be of curiosity to all virologists and especially to either verified staff and beginners to this box. V.
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Extra resources for Biochemistry and Biology of Coronaviruses
26 - 29 ,33,34 OC-43 has also been detected in cell cultures by hemadsorption (HAd) tests with rat or mouse cells. 34 A plaque-reduction neutralization test for Oc-43 in MA-32l microcultures has been described which appears to be more sensitive than the HI test for measuring human serologic response to infection. 33 Finally, antibody response to OC-43 infection measured by solid-phase radioimmunoassay (RIA) wa~5found to be comparable to that measured by CF, HI, or SRH tests. Strain 229E is readily identified by serum neutralization (SN) tests in various cell cultures.
1 & 1. Peak titers of infectious intracellular virus at 22-24 hr were followed by peak titers of infectious extracellular and total virus and by peak levels of 3H-labeled virus at 26 hr postadsorption, when CPE was minimal. Maximum CPE was coincident with rapid autolysis of the virus as it remained at 35°C~ CPE was scaled from + (5% of cells v~bly affected) to +++ (20%) to 1+ (25%) to 4+ (100%) to 4 (all cells totally destroyed). that 229E contains five amino acids in concentrations of >8 mol%: aspartic acid, glutamic acid, leucine, serine, and valine.
Corrections for physical/chemical parameters and for virus concentration gave a fully corrected sedimentation coefficient (SZO,w) of 390 ± 16 S. The apparent molecular weight was then calculated to be 112 ± 5 x 10 6 daltons, so that the par3~cle weight of one OC-43 virion is approximately 18 ± 1 x 10- 17 g. 3u Other workers have reported somewhat different data. Pokorny et al. 32 Sheboldov et al. 39 However, calculation of sedimentation coefficients by this procedure is very approximate, as none of the controls or physical correction factors ~an be applied.