Bronchial Asthma: Principles of Diagnosis and Treatment by Niels G. Waller, Suzanne S. Teuber, M. Eric Gershwin

By Niels G. Waller, Suzanne S. Teuber, M. Eric Gershwin (auth.), M. Eric Gershwin, Georges M. Halpern (eds.)

...offers chapters written by means of probably the most revered authors within the field...a invaluable reference publication for basic care physicians in addition to experts who deal with sufferers bronchial asthma. the ultimate part, residing with bronchial asthma, units this e-book except the multitude of books at the subject.-Pediatric allergic reaction and Immunology

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Important products of neutrophils include toxic oxygen metabolites and various proteases in addition to prostaglandins, leukotrienes, thromboxanes, and PAF (14). In terms of lipoxygenase products, neutrophils produce predominantly LTB 4 . This contrasts with eosinophils and mast cells that produce predominantly LTC4 • Holtzman and colleagues were the first to correlate nonspecific airway hyperresponsiveness with airway inflammation. After exposure of dogs to ozone, they showed marked neutrophil infiltration on lung biopsy specimens.

This is based on inhibition ofPAFinduced bronchoconstriction by chlorpheniramine, but not atropine or 34 Smart and Casale indomethacin. PAF's airway effects may also be a result of the production and release of leukotrienes and/or neuropeptides (13). In vitro, PAF can contract human bronchial smooth muscle, but only in the presence of platelets. The relevant platelet factor is not known with certainty, but potential candidates include biogenic amines and arachidonic acid metabolites, especially TXA2 • The many other properties of PAF include the ability to induce eosinophil and neutrophil chemotaxis, increase airway vascular permeability, increase mucus production, and decrease mucociliary clearance.

Identifying target populations at high risk. JAMA 1990; 264:1683-1687. 24. Burney PGJ. Asthma mortality: England and Wales. J. Allergy Clin. /mmunol. 1987; 80:379-382. 25. Anderson HR and Strachan DP. Asthma mortality in England and Wales, 1979-89. Lancet 1991; 337:1357. Genetics and Epidemiology of Asthma 19 26. Dawson KP and Mitchell EA. Asthma in New Zealand children. J. Asthma 1990; 27:291-297. 27. Mitchell EA, Anderson HR, Freeling P, and White PT. Why are hospital admissions and mortality rates for childhood asthma higher in New Zealand than in the United Kingdom?

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