Carbohydrate Recognition: Biological Problems, Methods, and by Binghe Wang(eds.)

By Binghe Wang(eds.)

This e-book comprises contributions from interdisciplinary scientists to jointly deal with the difficulty of concentrating on carbohydrate attractiveness for the improvement of novel healing and diagnostic brokers. The e-book covers (1) organic difficulties regarding carbohydrate reputation, (2) structural components mediating carbohydrate popularity, (3) layout and synthesis of lectin mimics that realize carbohydrate ligands with excessive specificity and affinity, and (4) modulation of organic and pathological methods via carbohydrate recognition.Content:
Chapter 1 Mammalian Glycan Biosynthesis: construction a Template for organic attractiveness (pages 1–32): M. Adam Meledeo, Venkata D. P. Paruchuri, Jian Du, Zhiyun Wang and Kevin J. Yarema
Chapter 2 the jobs of Carbohydrate Binding in mobilephone Adhesion and irritation (pages 33–63): Ken Kitajima and Chihiro Sato
Chapter three The function of Carbohydrates in Viral Infections (pages 65–91): Gillian M. Air
Chapter four The function of Carbohydrates in Bacterial Infections (pages 93–106): Roland J. Pieters
Chapter five the jobs of Carbohydrate Binding in Fertilization (pages 107–132): David J. Miller
Chapter 6 Carbohydrate Biomarkers (pages 133–156): Yunfeng Cheng, Nanting Ni, Hanjing Peng, Shan Jin and Binghe Wang
Chapter 7 Galectins and their function in quite a few organic strategies (pages 157–180): Sarika Saraswati, Ashley Stanley Block and Alan B. Diekman
Chapter eight Glycoimmunology (pages 181–203): Ani Grigorian, Barbara Newton and Michael Demetriou
Chapter nine instruments for Glycomics: Glycan and Lectin Microarrays (pages 205–227): Christopher Campbell and Jeff Gildersleeve
Chapter 10 Combinatorial Biosynthesis of complicated Carbohydrates (pages 229–255): Hai Yu and Xi Chen
Chapter eleven Mass Spectrometry in Carbohydrate Sequencing and Binding research (pages 257–300): Gregory O. Staples and Joseph Zaia
Chapter 12 artificial Lectin Mimics synthetic Carbohydrate Receptors (pages 301–327): Xiaochuan Yang, Yunfeng Cheng and Binghe Wang
Chapter thirteen Lectin Binding and its Structural foundation (pages 329–347): Annabelle Varrot, Bertrand Blanchard and Anne Imberty
Chapter 14 Multivalency in Carbohydrate Binding (pages 349–370): Mark L. Wolfenden and Mary J. Cloninger
Chapter 15 Carbohydrate Binding brokers: power Therapeutics with a number of Inhibitory activities opposed to Enveloped Viruses (pages 371–407): okay. O. Francois and J. Balzarini
Chapter sixteen Informatics for Glycobiology and Glycomics (pages 409–426): Kiyoko F. Aoki?Kinoshita

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For example, GalNAc analogs can be converted to UDPGalNAc by salvage or recycling mechanisms and then used by GalNAc transferases for incorporation into mucin-type O-glycans and possibly GAGs (Fig. 8a). However, UDP-GalNAc analogs are not converted to UDP-GlcNAc, or vice versa, even though the natural forms of these nucleotide sugars are readily epimerized to each other. Perhaps even more remarkably, salvaged GlcNAc analogs eschew all but one route into glycans, bypassing opportunities to enter N-linked glycans or be converted to ManNAc for sialylation or, returning the favor, not becoming UDP-GalNAc; instead selective incorporation in nucleocytosolic O-GlcNAc-modified proteins occurs.

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