Cellular Bioenergetics: Role of Coupled Creatine Kinases by Valdur A. Saks, Renée Ventura-Clapier

By Valdur A. Saks, Renée Ventura-Clapier

Most of the knowledge at the useful position, constitution and molecular biology of creatine kinase is scattered in numerous 1000s of courses. The editors of this quantity invited all authors who're such a lot lively at the present in experimental learn on creatine kinases to summarize their paintings and make the knowledge simply to be had to a much wider medical viewers, in particular to younger investigators who're coming into this box. because the practical function of coupled creatine kinases is at once on the topic of the phenomenon of compartmentation and structural association of metabolic networks, we additionally invited specialists within the comparable components to give a contribution to the amount. just about all invited authors replied enthusiastically and the result of this collective paintings are provided right here.
For biochemists, biophysicists, physiologists, and scientific study employees.

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Extra resources for Cellular Bioenergetics: Role of Coupled Creatine Kinases

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Note the biphasic responses ofNADH redox state and perfusion, in contrast to the steady decline in the forward rate constant of creatine kinase (Kf ) and flux of PCr to ATP during and after ACH infusion. HR x SBP =heart rate x systolic blood pressure; CO =cardiac output (IImin); MVOz =oxygen consumption (mllmin/l00 gm heart); PCr =phosphocreatine peak area; NADH =nicotinamide adenine dinucleotide (normalized to 100% Nz); Perfusion =ml/min/l00 gm eH NMR). crease. NADH fluorescence decreased and myocardial perfusion increased.

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Circ Res 66: 135-146, 1990 Marban E, Koretsune Y, Corretti M, Chacko VP, Kusuoka H: Calcium and its role in myocardial cell injury during ischemia and reperfusion. Circulation 80(suppl IV): IVI7-IV22, 1989 Pierce GN, Maddaford TG, Kroeger EA, Cragoe EJ: Protection by benzamil against dysfunction and damage in rat myocardium after calcium depletion and repletion. Am J Physiol 258 (Heart Circ PhysioI27): HI7-H23, 1990 Ponce-Homos JE, Musi EA, Bonazzola P: Role of extracellular calcium on heart muscle energetics: effects of verapamil.

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