Chemical Biology: Approaches to Drug Discovery and by Natanya Civjan

By Natanya Civjan

An authoritative examine the applying of chemical biology in drug discovery and development

Based at the award-winning Wiley Encyclopedia of Chemical Biology released in 2008, this booklet explores the function of chemical biology in drug discovery and improvement. the 1st a part of the booklet studies key ideas and strategies utilized in the layout and evaluate of drug applicants. the second one half elucidates organic mechanisms of yes ailments, illuminating methods to enquire and objective those diseases.

Comprising conscientiously chosen reprints from the Encyclopedia in addition to new contributions from prime students within the box, this publication presents researchers in academia and with vital info to assist within the improvement of novel brokers to regard illness. Self-contained articles disguise various crucial issues, including:

  • The layout, improvement, and optimization of drug candidates
  • The pharmacokinetics and houses of drugs
  • Drug shipping and delivery
  • Natural items and average product types as pharmaceuticals
  • Biological mechanisms underlying healthiness and disease
  • Treatment recommendations for a number of illnesses, from HIV to schizophrenia

Chemical Biology is a top-notch consultant and reference for somebody operating within the parts of drug discovery and improvement, together with researchers in chemical biology and different fields equivalent to biochemistry, drugs, and pharmaceutical sciences

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Extra resources for Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease

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Res. Rev. 2003;23:606–632. 36. Schneider G, Fechner U. Computer-based de novo design of drug-like molecules. Nat. Rev. Drug. Discov. 2005;4:649–663. 37. Chen G, Zheng S, Luo X, Shen J, Zhu W, Liu H, Gui C, Zhang J, Zheng M, Puah CM, Chen K, Jiang H. Focused combinatorial library design based on structural diversity, druglikeness and binding affinity score. J. Comb. Chem. 2005;7:398–406. 38 COMPUTATIONAL APPROACHES TO DRUG DISCOVERY AND DEVELOPMENT 38. Li J, Chen J, Zhang L, Wang F, Gui C, Zhang L, Qin Y, Xu Q, Liu H, Nan F, Shen J, Bai D, Chen K, Shen X, Jiang H.

Leach AR, Shoichet BK, Peishoff CE. Prediction of protein-ligand interactions. Docking and scoring: successes and gaps. J. Med. Chem. 2006;49:5851–5855. 26. Kurogi Y, Miyata K, Okamura T, Hashimoto K, Tsutsumi K, Nasu M, Moriyasu M. Discovery of novel mesangial cell proliferation inhibitors using a three-dimensional database searching method. J. Med. Chem. 2001;44:2304–2307. 27. Wolber G, Langer T. LigandScout: 3-D pharmacophores derived from proteinbound ligands and their use as virtual screening filters.

71. Littman BH, Krishma R. Translational Medicine and Drug Discovery. 2011. Cambridge University Press, New York. 2 COMPUTATIONAL APPROACHES TO DRUG DISCOVERY AND DEVELOPMENT Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and Hualiang Jiang Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China Recently, computational approaches have been considerably appreciated in drug discovery and development. Their applications span almost all stages in the discovery and development pipeline, from target identification to lead discovery, from lead optimization to preclinical or clinical trials.

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