By Feng Si-shen, Stanford Chong, Jenny Rompas
This booklet is a suite of the main courses of the authors within the rising zone of chemotherapeutic engineering. It describes and demonstrates the concept that, feasibility, defense and prospect of chemotherapeutic engineering via a whole spectrum of proof-of-concept experiments from layout, characterization, in vitro mobile uptake, cytotoxicity, to in vivo pharmacokinetics, biodistribution, and xenograft tumor version of many of the nanocarriers, similar to prodrugs, micelles, liposomes, and nanoparticles of biodegradable polymers. Read more...
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Additional resources for Chemotherapeutic Engineering: Collected Papers of Si-Shen Feng—A Tribute to Shu Chien on His 82nd Birthday
G. leukemia). Chemotherapy, radiotherapy, and immunotherapy, or their combinations become the main treatment procedures in these situations. New methods and techniques are under development and have been a focus in modern medicine, science and technology (Calabresi & Schein, 1993; Cavalli, Hansen, & Kaye, 1997; Morris, Kearsley, & Williams, 1998; Pazdur, 1995). In the literature, chemotherapy sometimes is deﬁned as the use of any medicine for treatment of any disease. Chemotherapy for cancer, however, is understood in a narrower sense of using chemotherapeutical agents directed at killing or controlling the cancer cells, and the cancer chemotherapeutic agents are often toxic or even life-threatening.
The nanoparticles can be administrated through various November 14, 2013 12:41 PSP Book - 9in x 6in 01-Feng–Chong-01 Proof-of-Concept Experimental Results routes such as oral, intravenous, nasal, ocular and transdermal routes. While delivering the bioactive molecules into the diseased cells, the polymeric matrix degrades and eventually disappears. Complete degradation can be made from a few hours to a few days or even a few months according to the needs, depending on the physicochemical properties of the polymers, which are determined and thus adjustable by their molecular structure and molecular weight.
58: 4087–4114, 2003; (The Most Cited Paper Award 2003–2006). 5. Feng, S. , and G. F. Huang. Eﬀects of phospholipids as emulsiﬁers on controlled release of Paclitaxel from nanospheres of biodegradable polymers. J. Control. Release 71: 53–69, 2001. 6. Feng, S. , L. Y. Zhao, Z. P. Zhang, G. Bhakta, K. Y. Win, Y. C. Dong, and S. Chien. Chemotherapeutic engineering: vitamin E TPGS-emulsiﬁed nanoparticles of biodegradable polymers realized sustainable Paclitaxel chemotherapy for 168 hours in vivo. Chem.