Chronobiotechnology and Chronobiological Engineering by Franz Halberg (auth.), Lawrence E. Scheving Ph.D., Franz

By Franz Halberg (auth.), Lawrence E. Scheving Ph.D., Franz Halberg M.D., Charles F. Ehret Ph.D. (eds.)

High blood strain (BP) (with fat and smoking) is among the 3 roots of cardio-cerebro-renovascular affliction affecting as much as 25% of the grownup inhabitants. consequently, hypertension will be well-known and taken care of, to lessen any issues and lengthen existence, as famous by way of Michael Weber of the Veterans management clinic in lengthy seashore, California. He extra emphasizes the necessity for tracking earlier than one begins the remedy of hypertension. certainly, he refers back to the result of the Australian research on light high blood pressure with a wide percent of placebo­ responders and rightly means that many folks are handled who shouldn't be due to 'white-coat-associated excessive blood pressure'. He additionally issues to the inability of standardization of options for information research and of equipment of BP size. Ambulatory tracking lower than traditional condi­ tions with no concomitant recording of occasions doesn't enable even a qualitative overview of the impression of various stimuli, in weber's opinion.

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Four other groups, each consisti ng of 8 patients, received Rx either 4 or 8 hours before or after their tumors' temperature peal:. (I I F-nJu. ere about 30'1 of thei r origi nal size in patients ..... ho received Rx at the peal: tumor temperature time. The tumors in patients ..... ho received the same Rx 8 hours after thei r tumor's peal: temperature ti me had shrunl: to only slightly less than 70'1 of their original size, as seen on the left of Figure 8. Details of various approaches, all validating the merits of chronotherapy, are given in Table 4.

Hich it has been sho.... n that by treati ng at the 'right' ti me with the 'right' schedule of doses, tolerance can be increased under controlled laboratory conditions. Cases in poi nt are drugs acti ng upon a breast cancer and a plasmacytoma of the rat; geins of up to several hundred per cent \t'ere obtained by the timing of si ngle or multi pIe-agent chemotherapy (Hal berg and Del barre, 1977; Hal berg and Hal berg, 1984). These experi mental gai ns complement the cli nical gai n of tW"O-a doubli ng of therapeutic benefit-from chronoradiotherapy, shown in Figure 6.

Men or of the ti me :ro to r of day. 0 LEUKEMIA TEST d results, a chronotherapy of OF .... ·C TREATMENT WITH EQUAL· DOSE SCHEOULE 11210 LEUKEM'A TEST b cancer was considered AND SINUSOIDAL SCHEOULE promisi 00. Several _u""'. ologists met with a group from the Notional Cencer " i Institute (USA) earl yin the 70s I" up acceptable rules for il totestidraw ng the effecti ve ness of " chronotherapy on laboratory ani mals. as decided to - compare survival ti mes followi ng the admi nistration of an anticancer drug, ara-C, acco rdi ng to 4 co urses of homeostatic (fixed-dose) and chronobiologic (sinusoidally-varyi no dose) schedules.

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