By Walter R. Wilson, W. Lawrence, MD Drew, Nancy K., Phd Henry, Merle A., MD Sande, David A., MD Relman, James M., MD Steckelberg, Julie Louise, MD Gerberding
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Extra info for Current Diagnosis & Treatment in Infectious Diseases
A. Immunoglobulin M. During the primary immune response, IgM antibodies are the first to be produced. The pentameric structure endows IgM with 10 antigen-binding sites. This assists in complement activation and aggregation of antigen and microbes. Antigen affinity for IgM is usually less than for IgG. Measurement of IgM antibody specificity and concentration is useful in diagnosis because its presence correlates with primary, active infection. B. Immunoglobulin D. IgD is expressed on the surface of B cells and functions as antigen receptor.
INNATE HOST DEFENSES DEFENSE MECHANISMS AT THE PHYSIOLOGIC LEVEL Introduction Numerous physiologic factors influence susceptibility to infection. Prime examples of these factors are discussed in the sections that follow. Normal Microbial Flora Body surfaces in continuity with the environment typically support a complex but characteristic set of numerous microbial species (Table 2-1). This group of microorganisms is called the normal flora and includes microorganisms that inhabit the integument, upper respiratory tract, gastrointestinal tract, and urogenital tract.
Protein-calorie malnutrition in children is associated with severe measles (rubeola virus). Historical observations point to reactivation of dormant tubercle bacilli during acute food shortage in populations with a high prevalence of this pathogen. Pyogenic bacterial infections and periodontal disease are additional examples. The original description of Pneumocystis carinii as a human pathogen was based on observations of pulmonary disease in starving European infants during and after World War II.