Current Therapy in Nephrology: Proceedings of the 2nd by J. Stewart Cameron (auth.), Vittorio E. Andreucci M.D.,

By J. Stewart Cameron (auth.), Vittorio E. Andreucci M.D., Antonio Dal Canton M.D. (eds.)

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Additional info for Current Therapy in Nephrology: Proceedings of the 2nd International Meeting on Current Therapy in Nephrology Sorrento, Italy, May 22–25, 1988

Sample text

Table. 1 Clinical findings at biopsy time Sex MIF Age at biopsy (yrs) Upper respire tract info Gross hematuria Microhem. andlor prot. Mean blood pres. (mmHg) Blood hemoglobin (g/dl) Serum IgA > 35B mg/dl Serum albumin (g/dl) Proteinuria (g/24h) Creatinine cl. (ml/min) Table 2. Glomerular chAnges: mild moderAte severe Tubular atrophy Interstitial fibre Interstitial info Arteriolar scler. 5 31 un Pas. 2 gr) and incidence of patients with serum IgA > 350 mg/dl (50% vs 55%). 01). 4:1). 05). 8%) and in 6 patiets of group 2 (60%).

25 H NaOH (to simulate the pH of the allopurinol solution)i group C was pretreated witb allopurinol (lOO mg/Kg) 'I bours before ADRi group D was treated witb tbe same dosage of allopurinol immediately after ADR adm1nistri'ition. e dye binding assay (3). on. When allopurinol was given 4 hours before ADR failed to prevent the progression of the renal disease: proteinuria in this group was only moderately lower than in the untreated rats on day to and day 15 (Tab. I, group C). A diffe- rent outcome of proteinuria was observed when allopurill0l was given immediately after ADR injection (Tab I, group D).

And dypiridamol 200 mg/ d. was undertaken 72 hours before ancrod suppression. Statistical analysis have been performed by using an HP XIU computer and the SPSS programs package. A bivariate correlation between serum creatinine level and disease evolution time by using the scattergram and pearson-corr procedures, was perfo~. RESUL TS In the group of patients receiving ancrod followed by P and CY -with/without plasma exchanges- significative changes of creatinine values during ancrod administration could not be seen.

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