By M. Constantine-Paton, J. J. Norden (auth.), S. Robert Hilfer, Joel B. Sheffield (eds.)
The eye has interested scientists from the earliest days of organic in vestigation. the range of its components and the precision in their interplay make it a favourite version procedure for various developmental reviews. the attention is a very necessary experimental procedure not just simply because its tissues supply examples of basic techniques, but additionally since it is a sought after and simply obtainable constitution at very early embryonic a long time. as a way to offer an open discussion board for investigators engaged on all points of ocular improvement, a sequence of symposia on ocular and visible devel opment was once initiated in 1973. a tremendous aim of the symposia has been to foster conversation among the fundamental study employee and the scientific neighborhood. it truly is our feeling that a lot could be discovered on each side from this interplay. the assumption for an off-the-cuff assembly permitting greatest ex switch of rules originated with Dr. Leon Candeub, who provided the nec essary motive force that made the sequence a truth. each one symposium has focused on a special element of ocular improvement. audio system were chosen to method comparable issues from assorted perspectives.
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Extra resources for Development of Order in the Visual System
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Small molecules can move through gap junctions from epithelial cells to underlying elongating fibers and then pass 200 microns into the lens interior via simple diffusion along the relatively broad cross sectional area of the fiber cell (Rae and Kuszak, 1983). This route is more efficient than the serial passage through the gap junctions between the hundreds of fibers that comprise the peripheral 200 microns of a lens, or diffusion in the restricted extracellular clefts. This transport "short circuit" may be highly significant because the peripheral 200 microns of a lens with a 3mm diameter, represents about 30% of the total number of fibers in such a lens and these fibers are the most active metabolically.
Just as we used localized tectal injections of HRP to establish the normal topography of tecto-isthmo-tectal connections, we employed the same techniques to study topography after early eye rotation (Udin & Keating, 1981). We used our knowledge of the normal connections plus our electrophysiological maps to predict how the isthmotectal topography would differ from normal. For example, after rotation of one eye by 1800 , an isthmotectal axon which normally projects to rostral tectum should move to a caudal position, and an axon which normally projects to caudal tectum should be rerouted to rostral tectum.