By Frank Eisenhaber
This anthology provides serious stories of tools and high-impact purposes in computational biology that bring about effects that non-bioinformaticians also needs to recognize to layout effective experimental examine plans. gaining knowledge of Biomolecular Mechanisms with Computational Biology explores the method of translating series strings into organic wisdom and considers exemplary groundbreaking effects comparable to unforeseen enzyme discoveries. This ebook additionally summarizes non-trivial theoretical predictions for regulatory and metabolic networks that experience acquired experimental confirmation.
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Extra info for Discovering biomolecular mechanisms with computational biology
Who's your neighbor? New computational approaches for functional genomics. Nat Biotechnol 2000; 18:609-613. 9. Gclfand MS, Mironov AA, Jomantas J et al. A conserved RNA structure element involved in the regulation of bacterial riboflavin synthesis genes. Trends Genet 1999; 15:439-442. 10. McGuire A M , Hughes J D , Church G M . Conservation of D N A regulatory motifs and discovery of new motifs in microbial genomes. Genome Res 2000; 10:744-757. 11. van Nimwegen E, Zavolan M, Rajewsky N et al. Probabilistic clustering of sequences: Inferring new bacterial regulons by comparative genomics.
A rational approach to Reengineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2 C 5 . J Biol C h e m 2 0 0 3 ; 278(19):17178-17184. 17. Jones D T , T h o r n t o n JM. Potential energy functions for threading. Curr Opin Struct Biol 1996; 6(2):210-216. 18. Jones D T . Progress in protein structure prediction. Curr O p i n Struct Biol 1997; 7(3):377-387. 19. Sippl MJ, Flockner H . Threading thrills and threats. Structure 1996; 4(1):15-19. 20. Murzin A G , Brenner SE, Hubbard T et al.
Nature 2002; 415:88-92. 76. Letunic I, Goodstadt L, Dickens NJ et al. Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res 2002; 30:242-244. 77. Stuart J M , Segal E, Koller D et al. A gene coexpression network for global discovery of conserved genetic modules. Science 2003; 302:249-255. 78. Ito T, Chiba T, Ozawa R et al. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc N a d Acad Sci USA 2 0 0 1 ; 98:4569-4574. 79. Krogan NJ, Peng W T , Cagncy G et al.