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Additional info for DNA Topoisomerases: Biochemistry and Molecular Biology
Protein conformational change involving at least one of the flanking domains during each cycle of the reaction might be required for the gate formation. Fluorescence and circular dichroism spectroscopic studies have demonstrated that the apo and Zn forms of E. , 1993). The DNA-flanking domain complex may move away from the cleavage site as a unit to create the gate. , 1990). Although the C-terminal region of the protein beyond Asp-760 is not 28 Yuk-Ching Tse-Dinh essential for the activity of the enzyme (Zumstein and Wang, 1986),cleavage of topoisomerase I with trypsin at Arg-744 generates a 14-kDa protease-resistant fragment that can be retained on single-stranded agarose and requires 400 mM NaCl for elution (Beran-Steed and Tse-Dinh, 1989).
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