Drug Therapy in Dermatology (Basic and Clinical Dermatology) by Larry E. Millikan

By Larry E. Millikan

This systematically geared up assortment evaluates the effectiveness of prescribed drugs and considers complicated dermatological stipulations that could require a number of techniques, offering information for applicable choice, initiation, and follow-up of drug treatment. Covers remedies for psoriasis starting from coal tar, anthralin, and phototherapy to topical steroids and diverse systemic brokers, together with methotrexate and cyclosporine! Richly exact with over 1400 references, tables, pictures, and drawings, Drug remedy in Dermatology ·focuses at the administration of the cutaneous adjustments of significant autoimmune connective tissue illnesses ·covers psoralen photosensitization and photochemotherapy ·examines ordinary and artificial retinoids ·discusses remedy for urticarial vasculitis, actual urticarias, urticaria pigmentosa, and call and papular urticaria ·emphasizes pharmacodynamic ideas that impact the choice of acceptable antimicrobial treatments ·describes topical treatments for zits, rosacea, and infections attributable to Staphylococcus aureus ·reviews the efficacy and toxicity of topical corticoids ·and extra! Addressing relatives historical past, inner and exterior remedies, and sufferer psychology, Drug remedy in Dermatology is a top-shelf reference for dermatologists, pharmacologists, pharmacists, internists, rheumatologists, allergists, kinfolk physicians, pediatricians, immunologists, biochemists, and graduate and scientific institution scholars in those disciplines.

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Extra resources for Drug Therapy in Dermatology (Basic and Clinical Dermatology)

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This is not surprising since they were conducted many years ago, but there are several good comparative studies worthy of comment. For example, in impetigo, fusidic acid ointment was shown to be significantly more effective than its vehicle [91]. Another comparative study in the same indication showed that fusidic acid was superior to a neomycin/bacitracin combination [92]. The comparative clinical and bacteriological efficacy of fusidic acid and mupirocin has been investigated in several clinical studies [93–99].

J Am Acad Dermatol 1984; 11:86–89. 26. Chalker DK, Shalita A, Smith JG, Swann RW. A double-blind study of the effectiveness of a 3% erythromycin and 5% benzoyl peroxide combination in the treatment of acne vulgaris. J Am Acad Dermatol 1983; 9:933–936. 27. Shalita AR, Chalker DK, Ellis CN, et al. A multicenter, double-blind controlled study of the combination of erythromycin/benzoyl peroxide, erythromycin alone and benzoyl peroxide alone in the treatment of acne vulgaris. Cutis 1992; 49:1– 4. 28.

These commonly reported values give the physician an idea of whether the organism is susceptible to the antimicrobial agent, whether the antimicrobial is bactericidal or bacteriostatic, and what concentrations must be exceeded at the site of infection if therapy is to result in eradication of the infection [2]. They do not, however, adequately describe the rate and extent of the antimicrobial effect, the inoculum effect, the effects of subinhibitory concentrations [3], the postantibiotic effect [4], and the postantibiotic leukocyte effect [5].

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