By Edwin R. Fisher (auth.), Prof. Dr. J. Zander, Prof. Dr. J. Baltzer (eds.)
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Extra info for Early Breast Cancer: Histopathology, Diagnosis and Treatment
Early stromal invasion out of the LeIS in two cases, both about 1-2 mm in diameter. Note the radial single-cell infiltration and the incipient "Indian file" pattern unique for invasive lobular cancer Lobular Carcinoma In Situ 51 close serial sectioning procedure. But sometimes we were lucky enough to find "early stromal invasion" of the lobular cancer (Fig. 2). Stromal microinvasion in the terminal ductules or lobules is always accompanied by extensive changes in the basement membranes and a radial single-cell infiltration in this area (Tulusan et al.
We divided the breast into four quadrants and a retromamillary area, and subjected the resected breast to total radial processing (Fig. 1) involving radiologic examination of each slice before embedding. We made only large-block sections, so that we were able to determine the topographic location of each lobular or ductal alteration found during the histological examination. In the course of these procedures, 6 (16%) invasive cancers were detected in the breasts of 38 LCIS patients treated within 24 months after the diagnosis of LCIS, 10% being detected within the first 12 months.
LOa, b. Lipid-secreting carcinoma: a paraffin section reveals the histiocytoid pattern with large, clear, vacuolated tumor cells; b staining with Sudan Black displays a marked lipid content with large lipid droplets and a homogeneous distribution. Formalin, frozen section , x 300 R. Bassler and C. Eckhardt 46 We were able to observe very wide variation in the grades of lipid production in intraductal carcinomas, particularly in comedocarcinoma. Higher grades of lipid production were found in papillary carcinomas (Fig.