By E. Grundmann (auth.), E. Grundmann, H. Grunze, S. Witte (eds.)
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Extra resources for Early Gastric Cancer: Current Status of Diagnosis
Cancer mortality for selected sites in 24 countries. IV, 1962-1963. Dept. of Public Health, Tohoku University, School of Medicine. Sendai: 1966. Snell,K. C. ,Stewart,H. L" Morris, H. P. : The sequential development of atrophy, precancerous lesions, and cancer of the glandular stomach, and other organs and tissues of rats ingesting N, N'- 2,7 -fluorenylenebisacetamide. ' 125-142 (1969): Stewart, H. L. ,Snell, K. C. ,Morris, H. P. : Histologic criteria for the diagnosis of experimentally induced carcinoma and precancerous lesions of the glandular stomach of inbred strains of rats and comparison with transplantability.
There is an in- 48 Fig. 5. Collections of inflammatory cells within atypical gland. H . E. x 285 creased mitotic activity as well as a decrease of the number of goblet cells, and a lining epithelium consisting of several layers. Specific conclusions cannot be drawn from this variant of intestinalisation which is so frequently seen that one must assume it to belong to the normal range of the picture of intestinalisation. Fig. 3. shows a gastric pit with a striking difference of the lining epithelium in its outer and deeper portions.
All the cases were accompanied by a widespread chronic gastritis with intestinal metaplasia in the remaining parts of the stomach. Uncomplicated intestinal metaplasia (Fig. 1) is characterised by the regularity of the glands which are, in general, straight without branching. Their main axis runs in right angles to the surface. The lining epithelium consists of a single layer of cells with basally situated nuclei and very numerous goblet cells. Mitotic activity is inconspicuous, the interstitial tissue shows little chronic inflammatory infiltration.