Ergebnisse der physiologie biologischen chemie und by H. H. Dale (auth.)

By H. H. Dale (auth.)

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Example text

Thus the concentration in this fluid was only 9 % of that in the plasma so that, because it is well established that sulphate and other extracellular tags can exchange between nervous tissue and cerebrospinal fluid, it seems very likely that the extracellular fluid would acquire a concentration that was closer to that in the cerebrospinal fluid than that in the plasma; if the extracellular fluid were in equilibrium with the cerebrospinal fluid the computed space would be t8--36% and clearly the true space will be between this and the 2--4% computed on the basis of complete equilibrium with the plasma.

The electron-microscopical evidence thus provides a plausible basis for dismissing the blood-brain barrier phenomenon as an indication only of the limited extraceUular space of the tissue, rather than the existence of a definite diffusion-resistance offered b y the membranes separating blood from this extracellular space. Before discussing further the ultrastructure of the nervous tissue, therefore, we m a y consider the justification, or otherwise, of this rejection of a barrier between blood and extracellular space.

The endothelium rests on a thin dense basement membrane. Thus the difference between plexus capillary and parenchymatous capillary resides in the presence of gaps in the endothelial cell membranes, and this could easily account for the absence of a barrier between plexus capillary and the surrounding connective tissue, the blood-cerebrospinal fluid barrier being a function of the choroidal epithelium. Since muscle capillaries have no endothelial intracellular fenestrations, however, we cannot attribute the presence of a bloodbrain barrier to the mere absence of fenestrations.

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