By Paul P. Glasziou
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Additional resources for Evidence-based Practice Workbook - Bridging the Gap between Health Care Research and Practice
However, it is usually not ethical or practical to conduct such a trial to assess harmful outcomes. Cohort study Outcomes are compared for matched groups with and without exposure or risk factor (prospective study). Case-control study Subjects with and without outcome of interest are compared for previous exposure or risk factor (retrospective study). FREQUENCY AND RATE Cohort study As above. Cross-sectional study Measurement of condition in a representative (preferably random) sample of people.
Conclusions: The present work in CHD-free middle-aged men is the ﬁrst prospective cohort study to observe a signiﬁcant inverse association between quantitatively assessed moderateto-high folate intakes and incidence of acute coronary events in men. Our ﬁndings provide further support in favour of a role of folate in the promotion of good cardiovascular health. Question Answer 1. What is the question (PICO) of the study? P I C O 2. What is the purpose of the study? 3. Which primary study type would give the highestquality evidence to answer the question?
You reply ‘pretty unlikely’ (which is as much as you know at the time) but say that you will try to ﬁnd out more precisely. Develop a clinical research question using PICO to help you give Mr Thomas more precise details about his prognosis: P Population/problem O = = Question: Frequency or rate Questions of frequency (prevalence) are about how many people in the population have a disease or health problem, such as what is the frequency of hearing problems in infants or the prevalence of Alzheimer’s disease in over 70-year-olds.