Functional Ultrastructure: Atlas of Tissue Biology and by o. Univ. Prof. Dr. med. Margit Pavelka, Prof. Dr. med. Dr.

By o. Univ. Prof. Dr. med. Margit Pavelka, Prof. Dr. med. Dr. sc. Dr. h. c. Jürgen Roth (auth.)

This atlas of useful ultrastructure offers a close perception into the advanced constitution and association of cells and tissues, highlights particular mobile and tissue services, and the dynamics of numerous intracellular techniques. hugely informative electron micrographs are complemented via explanatory texts, chosen references and schemes. the idea that subcellular organelles give you the structural beginning for basic techniques of dwelling organisms is emphasised. the 1st half covers the mobile organelles and adjustments because of experiments or taking place lower than pathological stipulations. the second one half illustrates by means of chosen examples rules of practical tissue association and regular adjustments because of experimental induction or pathological occasions.

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References Baumann O and Walz B (2001) Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int Rev Cytol 205: 149 English AR, Zurek N, and Voeltz GK (2009) Peripheral ER structure and function. Curr Opin Cell Biol 21: 596 Fagone P and Jackowski S (2009) Membrane phospholipids synthesis and endoplasmic reticulum function. J Lipid Res 50: S311 Galteau MM, Antoine B, and Reggio H (1985) Epoxide hydrolase is a marker for the smooth endoplasmic reticulum in rat liver.

As for other reported examples, it is currently unknown how such domains become established and are maintained. It has been proposed that the endoplasmic reticulum is a site of mRNA localization which will associate for their life time with membrane-bound polyribosomes. As a results the synthesis of the respective proteins will be compartmentalized. References Baumann 0 and Walz B (2001) Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int Rev Cyto1205: 149 Deschuyteneer M, Eckhardt AE, Roth J, and Hill RL (1988) The subcellular localization of apomucin and nonreducing terminal N-acetylgalactosamine in porcine submaxillar glands.

J BioI Chern 263: 2452 Ilnuma T, Aoki T, Arasaki K, Hirose H, Yamamoto A, Samata R, Hauri H, Arimitsu M, Tagaya M, Tani K (2009) Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains. J Cell Sci 122: 1680 Nicchitta CV (2002) A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. Curr Opin Cell BioI 14: 412 Nikonov AV, Snapp E, Lippincott-Schwartz J, and Kreibich G (2002) Active translocon complexes labeled with GFP-Dadl diffuse slowly as large polysome arrays in the endoplasmic reticulum.

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