Galectins and Disease Implications for Targeted Therapeutics by Anatole Klyosov, Peter G. Traber

By Anatole Klyosov, Peter G. Traber

content material: CONTENTS ; PREFACE ; review ; 1. GALECTINS IN affliction AND power healing ways ; ANATOLE A. KLYOSOV AND PETER G. TRABER ; GALECTIN AND GALECTIN INHIBITORS: STRUCTURAL facets ; 2. LOW-MOLECULAR WEIGHT INHIBITORS OF GALECTINS ; HAKON LEFFLER AND ULF J. NILSSON ; three. FROM CARBOHYDRATE TO PEPTIDOMIMETIC INHIBITORS OF GALECTINS ; KEVIN H. MAYO ; GALECTIN additional- AND INTRA-CELLULAR services AND ; THEIR healing IMPLICATIONS ; four. INTRACELLULAR GALECTINS: systems FOR meeting OF MACROMOLECULAR ; COMPLEXES ; JOHN L. WANG, KEVIN C. HAUDEK, PATRICIA G. VOSS, RONALD J. PATTERSON, AND ; ERIC J. ARNOYS ; five. GALECTINS AS NOVEL REGULATORS OF PLATELET SIGNALING and serve as: ; healing IMPLICATIONS ; GABRIEL A. RABINOVICH AND MIRTA SCHATTNER ; 6. GALECTIN-1 CROSS-LINKING OF GM1 GANGLIOSIDE IN AUTOIMMUNE ; SUPPRESSION ; ROBERT W. LEDEEN, GUSHENG WU, DAVID BLEICH, ZI-HUA LU, AND HANS-JOACHIM GABIUS ; 7. tips to construct "LEAN AND suggest" ANTI-TUMOR T CELLS: A STRATEGIC VIEW INTO ; THE ANTI-CARBOHYDRATE motion OF FLUORINATED GLUCOSAMINE ANALOGS ; CHARLES J. DIMITROFF ; eight. POST-TRANSLATIONAL amendment OF GALECTIN-3 AND ITS function IN organic ; functionality ; JAMES C. BYRD, NACHMAN MAZUREK, AND ROBERT S. BRESALIER ; GALECTIN MECHANISMS AND healing methods IN melanoma ; nine. THE position OF GALECTIN-3 IN MALIGNANT cancer ; GORDANA RADOSAVLJEVIC, IVAN JOVANOVIC, JELENA PANTIC, NADA PEJNOVIC, ; NEBOJSA ARSENIJEVIC, DANIEL ok. HSU, AND MIODRAG L. LUKIC ; 10. GALECTINS AS NOVEL pursuits FOR THE therapy OF MALIGNANT GLIOMAS ; HERWIG M. STRIK AND MATTHIAS OCKER ; eleven. DYNAMIC TUNING OF GALECTINS AND THEIR BINDING websites in the course of MAMMARY ; TUMOR development AND METASTASIS ; JOANA T. DE OLIVEIRA AND FATIMA GARTNER ; 12. GALECTIN-3C: HUMAN LECTIN FOR remedy OF melanoma ; GARY A. JARVIS, LEONARDO MIRANDOLA, YU YUEFEI, EVERARDO COBOS, ; MAURIZIO CHIRIVA-INTERNATI, AND CONSTANCE M. JOHN ; thirteen. ANGIOSTATIC melanoma remedy through concentrating on GALECTINS within the TUMOR ; VASCULATURE ; IRIS A. SCHULKENS, ARJAN W. GRIFFIOEN, AND VICTOR L. THIJSSEN ; 14. GALECTINS AND PATHOLOGIES: function OF GALECTIN-3 within the conversation ; among LEUKEMIA CELLS AND THE MICROENVIRONMENT ; NORA HEISTERKAMP, FEI FEI, AND JOHN GROFFEN ; 15. TRANSLATIONAL RATIONAL FOR THE scientific improvement OF OTX-008: a unique ; DRUG THAT INHIBITS GALECTIN-1 EXPRESSION IN HUMAN melanoma versions ; ERIC RAYMOND, LUCILE ASTRORGUE-XERRI, MARIA SEROVA, MARIA EUGENIA RIVEIRO, AND ; SANDRINE FAIVRE ; sixteen. bettering THE scientific EFFICACY OF melanoma VACCINES via concentrating on IMMUNE ; SUPPRESSION IN HUMAN TUMORS ; NATHALIE DEMOTTE, ARISTOTELIS ANTONOPOULOS, JEAN-FRANCOIS BAURAIN, GREGOIRE WIEERS, ; NICOLAS VAN BAREN, AND PIERRE VAN DER BRUGGEN ; 17. concentrating on GALECTIN-3 UNVEILS THE COMPLEXITY OF a number of MYELOMA: A ; candy CONTEXT ; LEONARDO MIRANDOLA, YUEFEI YU, CONSTANCE M. JOHN, MARJORIE JENKINS, ; EVERARDO COBOS, AND MAURIZIO CHIRIVA-INTERNATI ; 18. GALECTINS within the BLOOD flow: capability healing goals OF ; melanoma METASTASIS ; CARRIE A. DUCKWORTH AND LU-GANG YU ; GALECTIN MECHANISMS AND healing techniques IN ; irritation AND FIBROSIS ; 19. A healing position FOR GALECTINS IN ACUTE irritation? ; DIANNE COOPER ; 20. GALECTINS IN IMMUNE AND INFLAMMATORY illnesses: INSIGHTS FROM ; EXPERIMENTS WITH GALECTIN poor MICE ; DANIEL okay. HSU, RI-YAO YANG, AGNES FERMIN, AND FU-TONG LIU ; 21. AUTOIMMUNE problems IN GALECTIN-3 poor MICE ; VLADISLAV VOLAREVIC AND MIODRAG L. LUKIC ; 22. GALECTIN-3: A imperative REGULATOR OF persistent irritation AND TISSUE ; FIBROSIS ; NEIL C. HENDERSON, ALISON C. MACKINNON, CLAIRE ROONEY, AND TARIQ SETHI ; 23. THE function OF GALECTIN-3 IN STELLATE mobile ACTIVATION AND LIVER FIBROSIS ; pleasure X. JIANG, XIANGLING CHEN, HIROO FUKADA, DAN ok. HSU, FU-TONG LIU, AND ; NATALIE J. TOROK ; 24. GALECTIN-3 MEDIATED CARDIOVASCULAR FIBROGENESIS: a tremendous explanation for ; center FAILURE AND CARDIOVASCULAR MORTALITY ; WOUTER C. MEIJERS AND RUDOLF A. DE BOER ; 25. MUCINS AND GALECTIN-3 IN OCULAR floor well-being AND illness ; JEROME MAURIS AND PABLO ARGUESO ; 26. function OF GALECTINS IN WOUND therapeutic ; NOORJAHAN PANJWANI, PH.D. ; EDITORS' BIOGRAPHIES ; INDEXES ; writer INDEX ; topic INDEX

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Extra resources for Galectins and Disease Implications for Targeted Therapeutics

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It is now time for efforts to shift from academic descriptions and experiments into pharmaceutical development. As part of this effort, as stated above, the current set of therapeutic agents need to be characterized in relation to binding and mechanism of action. The diseases to target need to be carefully chosen based on the relevance to human disese. While there is some data in human cancer, careful thought needs to be given to the right cancers and approach to therapy, including combinations with existing therapy.

2011, 38, 1453–1464. 31. ; Lefranc, F. Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas. Anticancer Res. 2011, 31, 953–958. 32. ; Ruysschaert, J. ; Lefranc, F. Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression. Neoplasia 2011, 12, 727−739. Erratum in Neoplasia 2011, 13 (9), following p 886. 33. Klyosov, A.

Strik, H. ; Rabinovich, G. ; Bähr, M. Galectin-1 expression in human glioma cells: Modulation by ionizing radiation and effects on tumor cell proliferation and migration. Oncol. Rep. 2007, 18, 483–488. 25. ; Kiss, R. Present and potential future issues in glionlastoma treatment. Expert Rev. Anticancer Therapy 2006, 6, 719–732. 26. ; Kiss, R. Galectin-1 mediated biochemical controls of melanoma and glioma aggressive behavior. World J. Biol. Chem. 2011, 2, 193–201. 27. ; Van Gool, S. W. Galectin-1 and immunotherapy for brain cancer.

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