By P. J. Lefèbvre (auth.), J. Picazo MD (eds.)
I am very happy to assert once more that i used to be thrilled at being invited to chair this 3rd overseas Workshop on Glucagon (Glucagon in 1987). the 2 prior ones have been held in Madrid lower than the auspices of the clinical college of the Universidad Complutense of that urban, the 1st in may perhaps 1978 and the second one in October 1981, which led to books (Glucagon in 1979, and Glucagon in Gastroenterology and Hepatology, 1982, Gastroenterology, either released by way of MTP Press), the place the mounting curiosity in and improve ments about the healing purposes of glucagon have been mirrored. This time the assembly used to be held in Barcelona lower than the auspices of the Escuela de Patologia Digestiva of the Universidad Aut6noma of Barcelona, a transformation that we specially welcomed since it isn't very usually that we can gather in our urban one of these amazing staff of scientists from around the world. As should be noticeable from the identify of the current booklet, this workshop focussed once more at the present prestige of glucagon in gastroenterology and hepatology, simply because even though a lot has been stated and mentioned in regards to the topic already, it nonetheless increases intriguing and exciting concerns for debate. there have been elements to this assembly. The gastroenterology consultation was once taken with the body structure and pathophysiology of glucagon within the gastrointestinal tract and its purposes in prognosis, endoscopy and radiology.
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Extra resources for Glucagon in 1987: Gastrointestinal and Hepatobiliary Physiology, Diagnosis and Treatment
The use of Pro-Ban thine to induce gastrointestinal hypotonia. Radiology 1978; 127: 61-62. 6. Gelfand DW, Moskowitz M. Massive gastric dilatation complicating hypotonic duodenography. Radiology 1970; 97: 637-639. 7. Chemish SM, Miller RE, Rosenak BD, Scholz NE. Effect of glucagon on size of visualized human gallbladder before and after a fat meal. Gastroenterology 1972; 62: 1218-1226. 8. Chemish SM, Miller RE, Rosenak BD, Scholz NE. Hypotonic duodenography with the use of glucagon. Gastroenterology 1972; 63: 392-398.
Hypotonic duodenography with glucagon. Radiology 1973; 108: 35-42. 2. Miller RE, Chemish SM, Skucas J, Rosenak BO, Rodda BE. Hypotonic roentgenography with glucagon. Am ] Roentgenol1974; 121: 264-274. 3. Meeroff Je J0rgens J, Isenberg JI. The effect of glucagon on barium enema examination. Radiology 1975; 115: 5-7. 36 GLUCAGON IN UPPER GASTROINTESTINAL RADIOLOGY 4. Kreel L. Pharmaco-radiology in barium examination with special reference to glucagon. Br ] Rlldio11975; 48: 691-703. 5. Ishii H, Kamiya T, Oda Y, Okuno F, Takagi S, Aiso S, Yoshizawa M, Tsuchiya M.
See increases in blood glucose levels, in free fatty acid levels, and in ketone bodies; so, from the metabolic point of view, diabetics are extremely and exquisitely sensitive to glucagon, and therefore it is hard to figure out why there is a lack of effect; but, of course, on the other hand, most diabetics have some degree of autonomic neuropathy, and the explanation may be that, in some way, this is responsible for the lack of effect of glucagon. Whether this has been published or documented I do not know, but I think that this 52 LOWER GASTROINTESTINAL TRACT RADIOLOGY WITH GLUCAGON lack, or relative lack of efficacy of glucagon in diabetics is an extremely important finding.