Integrative medical biochemistry : examination and board by Michael W. King

By Michael W. King

Crucial for USMLE Step 1 evaluate!

A rigorous full-color assessment for any form of biochemistry or scientific biochemistry examination!

Integrative clinical Biochemistry exam and Board Review is a quick and potent manner so that you can organize for normal direction examinations in biochemistry and clinical biochemistry, in addition to scientific board checks and the USMLE Step 1. a distinct characteristic of this overview is the mixing of clinical biochemistry with body structure, pathophysiology, pathology, and anatomy, making it excellent for latest swiftly altering scientific college curriculum. Integrative clinical Biochemistry exam and Board Review is logically divided into 4 sections:

  • Section 1 covers the fundamentals of the key construction blocks of all cells and tissues
  • Section 2 discusses metabolic biochemistry with a powerful emphasis on medical correlations and medical issues regarding those all vital pathways
  • Section 2 stories the Cellular...
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    A. abnormal glycogen B. cerebrosides C. glycosaminoglycans D. GM2 ganglioside E. neuraminic acid Answer B: Gaucher disease is characterized by the lysosomal accumulation of glucosylceramide (glucocerebroside) which is a normal intermediate in the catabolism of globosides and gangliosides. Gaucher disease results from defects in the gene encoding the lysosomal hydrolase: acid β-glucosidase, also called glucocerebrosidase. The hallmark feature of Gaucher disease is the presence of lipid-engorged cells of the monocyte/macrophage lineage with a characteristic appearance in a variety of tissues.

    A. the equilibrium constant for the ionization of the substance B. the ion constant of water C. negative log of the concentration of H+ D. pH at which a molecule is electrically neutral E. pH at which an equivalent distribution of acid and conjugate base exists in solution Answer D: The isoelectric point is that pH at which a substance exhibits no net charge. In other words, all the negative and positive charges, say for instance in a protein, are equal in number such that the molecule is electrically neutral.

    The ring structures of the carbohydrates can be depicted by either Fischer- or Haworth- (also called the chair form) style diagrams (Figure 2-5). The numbering of the carbons in carbohydrates proceeds from the carbonyl carbon, for aldoses, or the carbon nearest the carbonyl, for ketoses. The rings can open and reclose, allowing rotation to occur about the carbon bearing the reactive carbonyl yielding 2 distinct configurations (α and β) of the hemiacetals and hemiketals (Figure 2-6). The carbon about which this rotation occurs is the anomeric carbon and the 2 forms are termed anomers.

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