Lipids and Cellular Membranes in Amyloid Diseases by Raz Jelinek

By Raz Jelinek

Addressing one of many largest riddles in present molecular cellphone biology, this ground-breaking monograph builds the case for the the most important involvement of lipids and membranes within the formation of amyloid deposits. Tying jointly contemporary wisdom from in vitro and in vivo studes, and equipped on a valid biophysical and biochemical beginning, this assessment brings the reader modern with present versions of the interaction among membranes and amyloid formation.
Required interpreting for any researcher attracted to amyloid formation and amyloid toxicity, and attainable avenues for the prevention or remedy of neurodegenerative disorders.

From the contents:

* Interactions of Alpha-Synuclein with Lipids
* interplay of hIAPP and its Precursors with Membranes
* Amyloid Polymorphisms: Structural foundation and importance in Biology and Molecular Medicine
* The function of Lipid Rafts in Alzheimer's Disease
* Alzheimer's affliction as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases
* Impaired legislation of Glutamate Receptor Channels and Signaling Molecules by means of Beta-Amyloid in Alzheimer's Disease
* Membrane alterations in BSE and Scrapie
* Experimental methods and Technical demanding situations for learning Amyloid-Membrane Interactions

and more

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Extra resources for Lipids and Cellular Membranes in Amyloid Diseases

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B, 114, 4615–4622. N. (2008) Structural characteristics of a-synuclein oligomers stabilized by the flavonoid baicalein. J. Mol. , 383, 214–223. , and Cappai, R. (2008) Formation of a high affinity lipid-binding intermediate during the early aggregation phase of a-synuclein. Biochemistry, 47, 1425–1434. S. (2007) Effect of ions on the organization of phosphatidylcholine/phosphatidic acid bilayers. Biophys. , 93, 1630–1638. L. (2003) Conformational behavior and aggregation of a-synuclein in organic solvents: modeling the effects of membranes.

A. (2010) a-Synuclein mediates alterations in membrane conductance: a potential role for a-synuclein oligomers in cell vulnerability. Eur. J. , 32, 10–17. , and Windisch, M. (2010) Establishment of stably transfected rat neuronal cell lines expressing a-synuclein GFP fusion proteins. J. Mol. , 41, 80–88. W. (2010) Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of a-synuclein aggregation. J. Mol. , 395, 627–642. T. (2001) a-Synucleinenhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.

2004) 3-Hydroxychromone dyes exhibiting excited-state intramolecular proton transfer in water with efficient two-band fluorescence. New J. , 28, 687–692. M. (2009) Characterization of coupled ground state and excited state equilibria by fluorescence spectral deconvolution. J. , 20, 181–190. , and Duportail, G. (2006) Membrane dipole potential as measured by ratiometric 3-hydroxyflavone fluorescence probes: accounting for hydration effects. J. , 16, 35–42. , and Duportail, G. (2007) Fluorescent dyes undergoing intramolecular proton transfer with improved sensitivity to surface charge in lipid bilayers.

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