Lung Biology in Health & Disease Volume 197 Ion Channels in by Jason X.-J. Yuan

By Jason X.-J. Yuan

This quantity provides an international assessment of the function of ion flux through transmembrane ion channel proteins within the law of pulmonary vascular tone and within the vascular home improvement tactics linked to pulmonary vascular disease-offering a finished evaluate of the a number of households of ion channels which were pointed out and characterised in pulmonary artery delicate muscle, in addition to a pragmatic dialogue of experimental instruments for the examine of ion channel body structure and molecular biology.

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Additional info for Lung Biology in Health & Disease Volume 197 Ion Channels in the Pulmonary Vasculature

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Kþ channels that are modulated by intracellular ATP and nucleotide diphosphates have been described in pulmonary artery smooth muscle cells. However, it is thought that these channels play, at best, a minor role in generating Em in ‘‘nonstimulated’’ cells, because the sulfonylurea compound glibenclamide (10 mM), a relatively specific inhibitor of KATP, did not affect Em in rabbit (18) and rat (26) pulmonary myocytes dialyzed with a physiological concentration of ATP (3–5 mM) but significantly depolarized rabbit myocytes that had been hyperpolarized by the KATP channel agonist levcromakalim (27) or by cell dialysis with ATP-free pipette solution (18).

483 James S. K. Sham, Anita Umesh, Xiao-Ru Yang, and Mo-Jun Lin I. Introduction . . 483 II. Ryanodine Receptor: the Mediator of Ca2þ Sparks . . 484 III. Ca2+ Sparks of Systemic Vascular Smooth Muscle . . 492 xxii Contents IV. Ca2+ Sparks of PASMCs . . 494 V. Physiological Roles of Ca2+ Spark in PASMCs . . 502 VI. Concluding Remarks . . 503 References . . 504 24. Ion Channels and Hypoxic Pulmonary Vasoconstriction . . . . . . . . . . . . . . . . . . . . . 513 Vladimir A.

742 V. Concluding Remarks . . 746 References . . 746 37. Use of Transgenic and Gene-Targeted Mice to Study Ion Channel Function in the Pulmonary Vasculature . . . . . . . . . . . . . . . . . . . 751 Barry London and Maninder Singh Bedi I. Introduction . . 751 II. Generating Transgenic and Gene-Targeted Mice . . 752 III. Studying Transgenic and Gene-Targeted Mice . . 755 IV. Targeting Ion Channels in the Pulmonary Vasculature . . 757 V. Transgenic and Gene-Targeted Mouse Models of Pulmonary Vascular Disease .

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