By Yufeng Zheng
Magnesium Alloys as Degradable Biomaterials presents a finished evaluation of the biomedical functions of biodegradable magnesium and its alloys. Magnesium has visible expanding use in orthopedic and cardiovascular functions over the past decade, relatively for coronary stents and bone implants.
The e-book discusses the elemental innovations of biodegradation mechanisms in addition to techniques to regulate biodegradation mode and expense, microstructure, mechanical houses, corrosion resistance to physique fluid, and in vitro and in vivo biocompatibility.
The lately constructed consultant magnesium alloy systems―such as Mg-Ca, Mg-Zn, Mg-Sr, Mg-Ag, Mg-Li, and Mg-RE―are reviewed and their specified homes illustrated. additionally mentioned are the biodegradable magnesium alloys/aqueous answer interface theoretical version and power software prototypes, akin to for cardiology and orthopedic surgical procedure products.
Challenges of transitioning biodegradable magnesium alloys from uncooked fabrics to semi-products to ultimate clinical units are lined in addition to major findings of globally experimental stories. an awesome reference booklet for researchers within the zone of biodegradable metals, it provides the cutting-edge of magnesium alloys designed for biomedical applications.
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Additional info for Magnesium Alloys as Degradable Biomaterials
According to the literature, both inorganic ions and organic components have significant influence on the degradation procedure of metal alloys. A buffer electrolyte solution containing similar components to human blood plasma should be used for the in vitro biodegradation test (Z. Zhen et al. 2013). 2 Electrochemical Measurement Electrochemical measurement is the most common corrosion test for both industrial and biomedical alloys for its convenience. Electrochemical measurement is considered to gain instantaneous data on the corrosion rate of the materials while also elucidating some of the mechanisms resulting in this corrosion behavior (Song 2005).
Moreover, the degradation rate of pure Fe and Fe-based biodegradable materials is too slow. 2 is a summary of some existing Fe and its alloys investigated for biomedical application contributed by H. Li et al. (2014). 2 Mechanical property summary of existing Fe alloys. , Y. Zheng, and L. Qin. Progress in Natural Science: Materials International, 24, 414–22, 2014. ) 14 Magnesium Alloys as Degradable Biomaterials Another new type of biodegradable metallic material attracting lots of attention is Zn-based material.
Therefore, to avoid ethical and economical problems, cell culture medium with a more similar content of serum is needed and recommended in consideration of the mismatch of in vivo and in vitro cytotoxicity test results. Apart from the factors above, other common parameters, such as pH value and osmotic pressure, all affect in vitro cytotoxicity test results. It needs to be noted that the relatively high activity of Mg2+ also needs to be concerned. For example, it has been found that Mg ions interfere with the assay by promoting the conversion to formazan, which affects formazan-related experiments, such as XTT and MTT.