MHPG: Basic Mechanisms and Psychopathology by James W. Maas

By James W. Maas

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Extra resources for MHPG: Basic Mechanisms and Psychopathology

Example text

T h e catabolism of n o r e p i n e p h r i n e is d e ­ picted in Fig. 3 . N o r e p i n e p h r i n e as well as its metabolites can also b e c o n j u g a t e d in t h e b r a i n by t h e e n z y m e p h e n o l s u l f o t r a n s f e r a s e . I n s o m e animals, such as t h e rat, t h e m a j o r metabolites of N E f o u n d in t h e C N S exist in t h e c o n j u g a t e d f o r m . I n most a n i m a l species including m a n t h e p r i m a r y N E metabolites f o u n d in t h e c e n t r a l n e r v o u s system a r e t h e Om e t h y l a t e d , d e a m i n a t e d r e d u c e d metabolite M H P G a n d t h e d e a m i n a t e d r e d u c e d metabolite 3 , 4 - d i h y d r o x y p h e n e t h y l e n e glycol ( D H P G ) .

H o w e v e r , even u n ­ d e r t h e m o s t rigorously c o n t r o l l e d e x p e r i m e n t a l conditions plasma lev­ els of M H P G can, at best, p r o v i d e i n f o r m a t i o n c o n c e r n i n g n o r ­ e p i n e p h r i n e m e t a b o l i s m in t h e e n t i r e C N S only. I n f o r m a t i o n o n r e g i o n a l alterations in c e n t r a l n o r a d r e n e r g i c activity c a n n o t b e o b t a i n e d by this a p p r o a c h . VIII. Summary N u m e r o u s basic studies d e m o n s t r a t e t h a t u n d e r e x p e r i m e n t a l l y d e ­ fined a n d c o n t r o l l e d c o n d i t i o n s t h e r e is a g o o d c o r r e l a t i o n b e t w e e n c h a n g e s in i m p u l s e flow in c e n t r a l n o r a d r e n e r g i c n e u r o n s of t h e locus c o e r u l e u s a n d M H P G levels m e a s u r e d in b r a i n .

C. 1978. Psychopharmacology: A Generation of Progress (M. A. Lipton, A. DiMascio, and K. F. ), p p . 1 8 5 - 1 9 8 . Raven Press, N e w York. Salzman, P. , a n d Roth, R. H . 1979. Prog. Neurobiol. 1 3 , 1 - 6 0 . Schanberg, S. , Schildkraut, J. , Breese, G. , a n d Kopin, I. J. 1968. Biochem. Phar­ macol. 17, 2 4 7 - 2 5 4 . Sjoqvist, B. 1 9 7 5 . / . Neurochem. 2 4 , 1 9 9 - 2 0 1 . Stone, E. A. 1975. Life Sci. 16, 1 7 2 5 - 1 7 3 0 . Svensson, T . , B u n n e y , B. , and Aghajanian, G. K. 1975.

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