Molecular Biology of Neuroreceptors and Ion Channels by Alfred Maelicke (auth.), Alfred Maelicke (eds.)

By Alfred Maelicke (auth.), Alfred Maelicke (eds.)

This workshop used to be the second one of this sequence hung on the island of santorini within the Cycladic Sea. the 1st one ("Mechanism of motion of the Nicotinic Acetylcholine Receptor", NATO ASI Se­ ries H, vol. 10) came about in might 1986 and inquisitive about what used to be on the time the easiest studied of all neuroreceptors. This moment one, held in simple terms years later, demonstrates the im­ mense growth accomplished considering then within the box of neurorecep­ tors and ion channels. Molecular cloning options have now made to be had the first constructions of a complete array of ion channel proteins, and this in flip has make clear a few gen­ eral rules of the structure-function relationships of those vital parts of intercellular verbal exchange. the aim of this workshop used to be to discover the typical ele­ ments in gene and protein constitution of already cloned ion channel proteins, and to evaluate the prestige of alternative cloning tasks in development. It explicitly occupied with very lately released and unpublished effects. All contributors saved to those pursuits thereby demonstrating the very price of such paintings­ outlets for the development of science.

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1983). of chicken ciliary ganglion neurons 1986) (Higgins & Berg, 1987). , 1987c). , 1987), and immunoaffinity purifying AChRs from rat brain (Whiting & Lindstrom, 1987b). Immunoaffinity purified AChRs from rat brain were then used as immunogen to raise another library of mAbs for studies of AChRs from the brains of rats, cattle, and humans (Whiting & Lindstrom, in press). These studies are summarized in Figure 2. Immunoaffinity-purified neuronal AChRs were found to consist of only two kinds of subunits.

O. Box 85800 San Diego, CA 92138, USA Kent Keyser,1 INTRODUCTION Nicotinic acetylcholine receptors (AChRs) of muscle, brain, and ganglia belong to the ligand-gated cation channel family, whose most well-studied electric organs of Torpedo member californica is the AChR of the and related species. , 1987). , will 1988), different be discovered. , 1988). Monoclonal antibodies (mAbs) and cDNA derived from studying Torpedo AChRs elucidating the structure of Here we will combine the (G-proteins) clones initially have been useful tools in human muscle and neuronal AChRs.

Lee, J. and Heinemann, S. (1982) Molecular cloning of cDNA coding for the gamma subunit of the Torpedo acetylcholine receptor. Proc. Nat. Acad. Sci. 79:44664470. , Heinemann, S. and Patrick, J. (1985) Isolation of a clone coding for the alpha subunit of a mouse acetylcholine receptor. J. Neuroscience. 5:2545-2552. , Heinemann, S. and Patrick, J. (1986a) Isolation and sequence of cDNA clones coding for the precursor to the gamma-subunit of mouse muscle acetylcholine receptor. J. Neurosci. Res.

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