Molecular Diagnosis and Treatment of Melanoma by John M. Kirkwood

By John M. Kirkwood

Facilitating efforts to avoid cancer development, this updated reference offers the latest advances within the pathology, molecular biology, and remedy of cancer in early, high-risk, and complicated levels. Discusses development elements, cytokines, receptors, oncogenes, tumor suppressor genes, adhesion molecules, and proteases in cancer and examines the fitting use of interferon adjuvant treatment! Written through major experts from the U.S. and Europe, Molecular analysis and remedy of cancer · information the preclinical and scientific foundation for brand new vaccines in accordance with gangliosides and peptides · explains the jobs of chemotherapy and radiosurgery · experiences the molecular good points of cancer and precursor cells · describes the occasions considering induction and upkeep of antitumor T-cell reaction and numerous get away mechanisms from immune attractiveness · analyzes melanotic and dysplastic nevi · explores the opportunity of vaccines that set off antibodies in immunotherapy and vaccines in high-risk cancer · summarizes cytotoxic chemotherapy in treating metastatic cancer · elucidates whole-brain radiotherapy, surgical resection, and stereotactic radiosurgery in handling cancer mind metastasis · and extra! Containing key bibliographic citations for extra in-depth learn of specific subject matters, Molecular analysis and remedy of cancer is a wonderful source for oncologists, dermatologists, molecular and mobile biologists, immunologists, pathologists, pharmacologists, toxicologists, interns, citizens, fellows, and graduate and clinical institution scholars in those disciplines.

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J Pathol 1992; 167:187191. 54. Kageshita T, Yoshii A, Kimura T, Kuriya N, Ono T, Tsujisaki M, Imai K, Ferrone S. Clinical relevance of I-CAM-1 expression in primary lesions and serum of patients with malignant melanoma. Cancer Res 1993; 53:49274932. 55. van Duinen CM, van den Broek LJ, Vermeer BJ, Fleuren GJ, Bruijn JA. The distribution of cellular adhesion molecules in pigmented skin lesions. Cancer 1994; 73:21312139. 56. Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA. E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro.

Interactions between CD28 on the T cell and CD80 or CD86 on the APC appear to provide the major costimulatory signals. Early events in CD28-mediated signals transduction may include binding Page 31 and activation of phosphoinositide 3-kinase and the mitogen-activated protein kinase (MAPK) JNK1 (38). The latter protein kinase phosphorylates the transcription factor c-Jun and thereby activates AP-1 and NF-ATp. Furthermore, CD28 stimulation leads to the induction of an activating transcription factor, the CD28 responsive complex, which binds to the IL-2 promoter (39).

Anderson Cancer Center, Houston, Texas Philip O. D. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York Page xiii Douglas S. D. D. The Wistar Institute, Philadelphia, Pennsylvania John T. D. D. Visiting Assistant Professor, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Walter J. D. D. D. Department of Medicine V, University of Heidelberg, Heidelberg, Germany Page 1 PART I MOLECULAR FEATURES OF THE BIOLOGY OF MELANOMA. Page 3 1 Molecular Features of Melanoma Progression Ulrich Rodeck The Wistar Institute Philadelphia, Pennsylvania Dorothea Becker University of Pittsburgh Pittsburgh, Pennsylvania I.

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