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Extra info for New Concepts of Psychostimulant Induced Neurotoxicity
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In turn, the enhanced extravesicular levels of dopamine lead to oxidative stress through the generation of reactive oxygen species and dopamine quinones, and cause the long-lasting neuronal damage. Thus, we propose that acute behavioral INTERNATIONAL REVIEW OF NEUROBIOLOGY, VOL. 1016/S0074-7742(09)88003-3 43 Copyright 2009, Elsevier Inc. All rights reserved. 00 44 KITA et al. observation of subjects immediately following methamphetamine administration may provide insight into the long-lasting toxicity to dopaminergic neurons.
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