Pediatric Dermatology: Advances in Diagnosis and Treatment by I. Anton-Lamprecht, M.-L. Arnold (auth.), Prof.Dr. Rudolf

By I. Anton-Lamprecht, M.-L. Arnold (auth.), Prof.Dr. Rudolf Happle, Prof.Dr. Edouard Grosshans (eds.)

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Constipation. This is a common and underestimated problem, usually due to painful anal fissures. A lack of bulk in the diet contributes, and an important element of treatment is to increase this bulk content; this is perhaps most easily achieved by giving a daily dose of lactulose (Duphalac, Duphar), but also by ensuring an adequate dietary intake of fruit and vegetables. Nutritional Problems. The morbidity of DEB can be reduced very greatly by careful attention to nutrition. The major problem tends to be poor intake due both to dysphagia and to anorexia, secondary to constipation.

Dermatologica 162:91-103 5. Gerber LH, Helfgott RK, Gross EG, Hicks JE, Ellenberg SS, Peck GL (1984) Vertrebral abnormalities associated with synthetic retinoid use. J Am Acad DermatoI10(5): 817-823 6. Hassell JR, Pennypacker JP, Kleinmann HK, Pratt RM, Yamada KM (1979) Enhanced cellular fibronectin accumulation in chondrocytes treated with vitamin A. Cell 17: 821-826 7. Hixon EJ, Denine EP (1978) Comparative subacute toxicity of all-trans- and 13-cis-retinoic acid in Swiss mice. Toxicol Appl Pharmacol 44: 29-40 Treatment of Genodermatoses with Oral Retinoids: Risk of Bone Changes 45 8.

2. a Autosomal recessive ELI. Marked palmar keratosis. b Autosomal recessive nonerytbrodermic lamellar ichthyosis (NELl). Distinct, but compared with ELl, less marked palmar keratosis Autosomal Dominant Inheritance in Lamellar Ichthyosis: Genetic Evidence of a Third Type In one family we observed lamellar ichthyosis in four patients belonging to three consecutive generations (Fig. 4). In this family ichthyosis was present at birth and large gray scales covered the entire body including the flexural folds, palms, and soles.

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