By James P. Tam, Yi-An Lu, Qitao Yu (auth.), Xiao-Yu Hu, Rui Wang, James P. Tam (eds.)
The 5th chinese language Peptide Symposium, hosted by way of Lanzhou collage, used to be held at Lanzhou, China July 14-17, 1998, with 156 contributors, together with 30 scientists from overseas, representing 9 nations. The four-day convention was once either extreme and spiritually profitable. Our target for CPS-98 used to be to supply a discussion board for the alternate of information, cooperation and friendship among the foreign and chinese language medical groups, and we think this target was once met. The symposium consisted of eight classes with forty two oral and ninety poster displays, together with artificial tools, molecular variety and peptide libraries, constitution and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo layout and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry-biology-interface and not easy difficulties in peptides. The enthusiastic cooperation and ideal contributions have been pleasurable and the energetic reaction of the invited audio system contributed to the good fortune of the symposium. The displays have been of fine quality and represented the most up-tp-date and critical facets of peptide technology. Dr. package Lam of the college of Arizona and Dr. Yun-Hua Ye of Peking college have been the recipients of “The Cathay Award” subsidized by way of the H. H. Liu schooling origin, provided for his or her seminal contribution in peptide technological know-how and the chinese language Peptide Symposium. 4 notable younger scientists have been chosen through the organizing committee to obtain awards backed by way of Haikou Nanhai Pharmaceutical Co. Ltd. (Zhong He Group).
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Additional resources for Peptides Biology and Chemistry: Proceedings of the 1998 Chinese Peptide Symposium July 14–17, 1998, Lanzhou, China
Meldal, M. , J. Chem. Soc. , 1 (1995), unpublished) Immobilization of α-Chymotrypsin on zeolite for peptide synthesis in organic solvent Yun-Hua Ye, Guo-Wen Xing, Gui-Ling Tian and Chong-Xi Li Department of Chemistry, Peking University, Beijing, 100871, China Introduction Immobilization of an enzyme usually allows the enzyme molecule to maintain its catalytic activity while other processes that are detrimental to the enzyme, such as autolysis, are inhibited. Furthermore, the immobilized enzyme is much more stable than the free enzyme during the reaction, and can be used repeatedly for a long time.
Study of the nature of the H-bonding and the complex structure is currently underway. Table 1. The effect of water content of dichlorometane on the product yield. HY immobilized αchymotrypsin as catalyst. 6 Table 2. The reusabiliiy of HY immobilized α-chymotrypsin under different water content. 2 Effect of water content of dichloromethane The water content of organic solvent greatly influenced the activity of immobilized enzyme and the product yield. With HY immobilized α-chymotrypsin as an example, different amounts of water were added to the reaction.
G. , Int. J. , 36 (1990) 255. B. , J. Am. Chem. , 113 (1991) 4202. Application of DEPBT for the synthesis of N-protected peptide alcohols Gui-Ling Tian, Bin-Yuan Sun, Wei Wang and Yun-Hua Ye Department of Chemistry, Peking University, Beijing, 100871, China Introduction DEPBT 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT) is an organophosphorus compound developed by our group which can be used as an efficient coupling reagent for peptide synthesis . Recent studies have demonstrated that DEPBT can be used in either solution-phase or solid-phase synthesis .