By Ian H. Porter
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Extra info for Perinatal Genetics. Diagnosis and Treatment
First trimester abortions, occurring at ten to 12 weeks gestation and often following a normal 8-9 weeks ultrasound, may well be attributable to uterine fusion defects. A persisting septum in particular seems disadvantageous. However, uterine fusion defects more often co-exist with other causes of early repetitive losses. In contrast to uncertainty about their relationship to first trimester los ses, uterine fusion defects are widely accepted as causes of second trimester abortions. 92"95 Some claim that loss rates are higher with septate and bicornuate uteri than with unicornuate uterus and didelphys, but the data are not convincing.
Gestation (wks) at Time of Abortion A B C D 24 + — chromosomally abnormal A = New York City (n = 2517) B = London (n = 893) C = Hiroshima (n = 477) D = Honolulu (n = 1922) Figure 1 . Distribution of Chromosomally Abnormal and Normal Spontaneous Abortions by Gestational Age. DOROTHY WARBURTON ET AL. 28 Table 3. Distribution (Percent) of Karyotypes in 2517 Spontaneous Abortions, for Private and Public Patients: New York City Data. Karyotype Private No. % No. Public % No. 0 Total 868 1,649 2,517 * Includes mosaic trisomies and double trisomies.
44:151-178,1980. 40 DOROTHY WARBURTON ET AL. 7. , Epidemiology of chromosomal anomalies in spontaneous abor tions: prevalence, development and determinants. , Human Fetal Loss. Oxford: Oxford University Press, in press. , Very early pregnancy. , Perinatal Genetics. New York: Academic Press, pp. 3-21, 1986. , The relationship of maternal age and trisomy among trisomie spontaneous abortions. Amer. J. Hum. , 36:1349-1356,1984. , Monosomy X: a chromosomal anomaly associated with young maternal age.