Pheochromocytoma: Diagnosis, Localization, and Treatment by Karel Pacak

By Karel Pacak

Pheochromocytomas are infrequent yet treacherous catecholamine-producing tumors, which if ignored or now not accurately handled, will virtually continuously end up deadly. advised prognosis is, hence, crucial for powerful therapy, often via surgical resection. The manifestations are various and the tumor can mimic numerous stipulations, usually leading to both faulty diagnoses or a not on time diagnosis.

Reflecting the hot leaps in knowing this situation, Pheochromocytoma: prognosis, Localization, and Treatment presents a finished replace at the advancements within the prognosis, localization, administration and therapy of pheochromocytomas – supplying you with the most recent leading edge technology along most sensible medical perform. Written by means of the major names within the box, the textual content information the numerous advancements in knowing the genetics and biology of the tumors, coupled with technological advances within the fields of analytical chemistry, genomics, molecular biology and nuclear medicine.


The such a lot accomplished e-book on pheochromocytoma

  • Provides leading edge technology and scientific information
  • Written via the prime names within the box
  • Authors current their lately constructed novel biochemical try out for the prognosis of Pheochromocytoma

Content:
Chapter 1 advent (pages 1–2):
Chapter 2 ancient reviews (page 3):
Chapter three Pathology (pages 4–7):
Chapter four scientific Presentation of Pheochromocytoma (pages 8–29):
Chapter five present traits in Genetics of Pheochromocytoma (pages 30–40):
Chapter 6 Catecholamines and Adrenergic Receptors (pages 41–71):
Chapter 7 present developments in Biochemical prognosis of Pheochromocytoma (pages 72–92):
Chapter eight present tendencies in Localization of Pheochromocytoma (pages 93–108):
Chapter nine remedy of Pheochromocytoma (pages 109–113):
Chapter 10 destiny developments and views (pages 114–119):

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Extra info for Pheochromocytoma: Diagnosis, Localization, and Treatment

Example text

Examples of this process include the release of catecholamines induced by tyramine and amphetamine. Excessive release of catecholamines that accompanies hypoxic ischemia in part occurs by a similar mechanism. 4 Uptake and Metabolism of Catecholamines Produced by the Sympathoadrenal System Since the enzymes responsible for metabolism of catecholamines have intracellular locations the primary mechanism limiting the lifespan of catecholamines in the extracellular space is uptake by active transport, not metabolism by enzymes [422].

The SDHB gene (paraganglioma 4 gene) is located on chromosome 1p35 and its product is iron–sulfur protein. The SDHC gene (paraganglioma 3 gene) is located on chromosome 1q23 and encodes a large subunit of cytochrome b. The SDHA gene is located on chromosome 5p15 and encodes a flavoprotein. The iron–sulfur protein and flavoprotein are anchored to the mitochondrial inner membrane. The SDH genes encode the four subunits of mitochondrial complex II linked to the electron transport chain and the Krebs cycle.

Examples of this process include the release of catecholamines induced by tyramine and amphetamine. Excessive release of catecholamines that accompanies hypoxic ischemia in part occurs by a similar mechanism. 4 Uptake and Metabolism of Catecholamines Produced by the Sympathoadrenal System Since the enzymes responsible for metabolism of catecholamines have intracellular locations the primary mechanism limiting the lifespan of catecholamines in the extracellular space is uptake by active transport, not metabolism by enzymes [422].

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