Plant Cells (Advances in Biochemical Engineering by Zhong, Jian-Jiang, volume editor

By Zhong, Jian-Jiang, volume editor

The new achievements in engineering stories on plant telephone cultures are reviewed, integrated are the fuel focus results and bioprocess integration for the improved productiveness of plant secondary metabolites. The metabolic engineering of plant secondary metabolite pathways and recombinant protein creation from genetically transformed plant cells are brought. Large-scale plant micropropagation through somatic embryogenesis and bushy roots is mentioned for effective propagation of desease-free, genetically uniform and large quantities of vegetation in vitro in large quantities. Characterization and alertness of furry plant roots endowed with photosynthetic services can be lined during this certain quantity.

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103. 104. 105. 106. 107. 108. 109. 110. 111. 112. 113. 114. 115. 116. 117. 118. 119. 120. 121. 122. 123. 124. 125. 126. 127. 128. 129. 130. 131. 132. 133. 134. 135. 136. 137. 138. (Schwarz/Process Black Bogen) Jian-Jiang Zhong Smith MAL, Reid JF, Hansen AC, Li Z, Madhavi DL (1995) J Biotechnol 40:1 Miyanaga K, Seki M, Furusaki S (2000) Biotechnol Bioeng 67:493 Yanpaisan W, King NJC, Doran PM (1998) Biotechnol Bioeng 58:515 Wen ZY, Zhong JJ (1995) Biotechnol Tech 9:521 Bailey CM, Nicholson H (1989) Biotechnol Bioeng 34:1331 Curtis WR, Hasegawa PM, Emery AH (1991) Biotechnol Bioeng 38:371 Hooker BS, Lee JM (1992) Biotechnol Bioeng 39:765 Van Gulik WM, ten Hoopen HJG, Heijnen JJ (1993) Biotechnol Bioeng 41:771 Glicklis R, Mills D, Sitton D, Stortelder W, Merchuk JC (1998) Biotechnol Bioeng 57:732 Schlatmann JE, ten Hoopen HJG, Heijnen JJ (1999) Biotechnol Bioeng 66:147 Bailey CM, Nicholson H (1990) Biotechnol Bioeng 35:252 Kurata H, Furusaki S (1993) Biotechnol Prog 9:86 Smith JM, Davison SW, Payne GF (1990) Biotechnol Bioeng 35:1088 Shioya S, Shimizu K, Yoshida T (1999) J Biosci Bioeng 87:261 Schlatmann JE, Nuutila AM, Van Gulik WM, ten Hoopen HJG, Verpoorte R, Heijnen JJ (1993) Biotechnol Bioeng 41:253 Scragg AH, Morris P, Allan EJ, Bond P, Fowler MW (1987) Enzyme Microb Technol 9:619 Biddington NL (1992) Plant Growth Regul 11:173 Kim DI, Pedersen H, Chin CK (1991) Biotechnol Bioeng 38:331 Schlatmann JE, Moreno PRH, Vinke JL, ten Hoopen HJG, Verpoorte R, Heijnen JJ (1997) Enzyme Microb Technol 20:107 Mirjalili N, Linden JC (1995) Biotechnol Bioeng 48:123 Wang HQ (1998) PhD thesis, East China University of Science and Technology Pan ZW, Wang HQ, Zhong JJ (2000) Enzyme Microb Technol 27:714 Cho GH, Kim DI, Pedersen H, Chin CK (1988) Biotechnol Prog 4:184 Lee CWT, Shuler ML (1991) Biotechnol Tech 5:173 Songstad DD, Giles KL, Park J, Novakowski D, Epp D, Friesen L, Roewer I (1989) Plant Cell Rep 8:463 Stephanopoulos G (1994) Curr Opin Biotechnol 5:196 Shimizu K (2000) In: Zhong JJ (ed) Advances in applied biotechnology.

In Japan three submerged fermentation processes using plant cell cultures were developed by Mitsui Petrochemical Industries to produce berberine, ginseng and shikonin on scales from 4000 to 20,000 l. Only one of these, production of shikonin by suspension cultures Lithospernum erythrorhizon, can be considered a clear success. It has been operated since the early 1980s [3]. Difficulty in obtaining regulatory approval for use of these products as medicinals has impeded commercialization. 2001 10:11 Uhr Seite 29 (Schwarz/Process Black Bogen) Gas Concentration Effects on Secondary Metabolite Production by Plant Cell Cultures 29 gulatory reasons.

Annua as a function of culture age. Ethylene (˾); carbon dioxide (̆); oxygen (b) –1 Fig. 2. Specific oxygen consumption rate (g O2 g–1 dw h ) and biomass accumulation (gdw per culture flask) of A. annua from type ‘a’ cultures as a function of time. C. Linden et al. –1 Fig. 3. Specific oxygen consumption rate (g O2 g–1 dw h ) of A. annua from type ‘a’ cultures as a function of oxygen headspace concentration FDW/IDW g glucose / L concentrations continuously through a test might well lead to different culture behavior than that observed from conventional cultures.

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