By M. Glatzel, M. A. Klein, S. Brandner, A. Aguzzi (auth.), Dr. Martin H. Groschup, Prof. Dr. Hans A. Kretzschmar (eds.)
A entire knowing of the biology of prion illnesses is essential for hazard review as regards either people and animals. To additional the communique of the present wisdom and the trade of diagnostic applied sciences within the clinical group, a symposium at the 'Characterization and prognosis of Prion illnesses' used to be held from September 23-25, 1999 in Tübingen, Germany. the overpowering curiosity and the participation of greater than 500 scientists from 26 nations made this symposium the most important assembly ever held within the box. during this Supplementum to records of Virology twenty-six invited audio system comprehensively current their facts at the pathogenesis of prion illnesses in people and animals, on molecular mechanisms fascinated by the transmissibility throughout species limitations, on animal and in-vitro versions at present to be had for the detection and quantification of infectivity and at the characterization of prion lines. this option makes an attempt to mirror the present cutting-edge, yet can't very likely symbolize the entire spectrum of study within the prion field.
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Extra resources for Prion Diseases: Diagnosis and Pathogenesis
This is the first drug exhibiting such a tight specificity for scrapie. Studies involving the incubation of Congo red with other TSE agent strains would be of particular interest to confirm if this link is a general phenomenon. Acknowledgements We gratefully acknowledge Pr. M. Seman for the gift of MS-8209 and Pro C. Weissmann for providing us with Prp% mice. This project was supported by the "Programme interministeriel sur les ESST et les prions". B. is a recipient of a fellowship from the Fondation pour la Recherche Medicale (Paris, France).
Immunol Today 10: 229-231 33. van Keulen LJM, Schreuder BEC, Meloen RH, MooijHarkes G, Vromans MEW, Langeveld JPM (1996) Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. J Clin Microbiol 34: 1228-1231 34. Schreuder BEC, van Keulen LJM, Vromans MEW, Langeveld JPM, Smits M (1998) Tonsillar biopsy and Prpsc detection in the preclinical diagnosis of scrapie. Vet Rec 142: 564-568 Authors' address: Dr. M. K. Pharmacological manipulation of early Prpres accumulation in the spleen of scrapie-infected mice V.